Cytodiagnostics offers flexible solutions for development and manufacturing of vertical flow rapid test assays based on our noble-metal nanoparticles (gold and our unique gold nanourchins) in conjunction with MedMira's Rapid Vertical Flow Technology™.

Vertical flow technologies are membrane-based immunoassays in which samples and reagents flow vertically through a porous supportive membrane. While both vertical flow and lateral flow assays utilize specific antigen–antibody interactions for analyte detection, the assay architectures, fluid dynamics, and detection workflows differ significantly.

In vertical flow technologies, samples and reagents pass directly through the membrane rather than migrating laterally across it. This design offers several advantages over conventional lateral flow assays, including faster reaction kinetics, reduced assay times (typically less than 1 minutes), greater flexibility in assay design, and the ability to process larger sample volumes. These characteristics can contribute to improved analytical performance, particularly when testing complex biological specimens.

Vertical flow immunoassays can be used for rapid detection of antibodies and/or antigen(s) in a sample of interest. Samples can come from a wide range of application areas such as clinical, veterinary, agricultural, food, bio-defence and environmental industries. Detection sensitivity is generally in the lower nanogram per ml range even in complex sample matrices.


WHY CHOOSE US?


If you are looking for a customized assay to meet your unique research needs or need assistance in optimizing an existing assay for improved sensitivity, accuracy, or reproducibility, our LFA/VFA development service may be just what you need. Our team of experienced scientists can help you develop and optimize LFA/VFA assays that are tailored to your specific research goals and sample types.

By leveraging years of experience in nanoparticle manufacturing and assay development we can reduce the time from project inception to a finished product. Whether it is a smaller project or full-scale assay development project with the goal of launching a commercial product, Cytodiagnostics and CytoGroup are here to help. 

 

Common project types:

  • Antibody conjugation and screening
  • New assay development
  • Transfer and optimization of existing proof-of-concept assay into a flow based rapid test setting.

If you are interested in our custom assay development services please contact us and we would be delighted to discuss your project.

 

Custom Vertical Flow Assay Development

If you are looking to develop your own vertical flow assays but find the process challenging, our assay development branch, CytoGroup, is here to assist.

Specializing in the development of biosensors and diagnostic tools, CytoGroup offers comprehensive services to transform your concept into a fully functional commercial product.

Our team of experts will guide you through every stage of development, from design to manufacturing, ensuring your assay meets the highest standards of quality and performance.
Phase 1
Phase 2
Phase 3
Phase 4
Confidentiality Agreements are signed. Ideas will be thoroughly assessed with complete literature reviews
Labelling of Nanoparticles with either antibodies, aptamers, or other molecules. Complete initial conjugate studies.
Transfer Assay onto a Lateral flow or Vertical Flow Device. Establish optimized conditions.
Testing of Assay with relevant samples containing target of interest.